ANXA4 and lung cancer: Interestingly, the introduction of this peptide into cells did mimic the behavior of wild-type Fhit protein toward Annexin A4; in fact, the administration of a synthetic Tat-Fhit 7-13 peptide to lung cancer cells: a) blocked Annexin A4 translocation from cytosol to plasma membrane; b) acted synergistically with paclitaxel in triggering apoptosis of lung cancer cells; c) induced dramatic regression of A549 tumor xenografts in combination with paclitaxel.