Intriguingly, as Fhit loss is also involved in cancer cells refractory to paclitaxel and cisplatin [17, 30], the discovery of the Fhit-ANXA4 complex offers opportunities of investigation to search for novel mechanisms responsible for chemoresistance, an event connected to the failure of pharmacological treatment of cancer patients that accounts for their dismal prognosis. This evidence concerns the gene ANXA4 and cancer.