The isolation of Annexin A4 as a novel Fhit-interacting protein was a very interesting finding for further studies because of its oncogenic role in the pathogenesis of cancer [19, 28] and chemoresistance, assessed for the first time in renal cancer cells resistant to paclitaxel and then also highlighted with cisplatin in cancer cell lines of different types [35, 36]. Here, ANXA4 is linked to cancer.