After tumor protein lysate fractionation into cytosolic and plasma membrane fractions, we observed that Tat-Fhit 7-13 treatment reduced the extent of Annexin A4 translocation to the plasma membrane after in vivo administration of paclitaxel (Figure 3B), thus indicating that the reported effect on tumor shrinkage in mice treated with the Tat-Fhit 7-13 plus paclitaxel was mainly due to the ability of the peptide to trap Annexin A4 in the cytosol. The gene discussed is ANXA4; the disease is neoplasm.