Interestingly, treatment of OVCA432 cells with Bosutinib drastically reduced the ability of LPA to down-regulate E-cadherin localization in inter-cellular junctions as well as its overall expression, indicating that the blockade of Src activation prevented LPA-induced EMT and that Src is needed for induction of EMT of ovarian cancer cells. The gene discussed is CDH1; the disease is ovarian carcinoma.