Cisplatin- or etoposide-induced Noxa up-regulation, MCL-1 reduction, and apoptosis were also observed not only in HeLa cervical cancer cells, but also in MDA-MB-468 breast cancer cells, HN30 head and neck squamous carcinoma cells, and mouse embryonic fibroblasts [11] (Supplementary Figure S1D, S1E, and S1F). Here, PMAIP1 is linked to breast carcinoma.