In regard to molecular mechanisms of TCF3 antitumor effects, in Sézary syndrome (a subtype of T cell lymphoma) derived cells, no significant cell death induction was observed after E47 overexpression, whereas, up-regulation of proapoptotic genes including BCL2L11 and BIK have been seen [9, 26]. The gene discussed is BCL2L11; the disease is Sezary syndrome.