Wang et al. found that CCL5 and CCR5 interaction activates protein kinase Cδ (PKCδ), c-Src and hypoxia-inducible factor-1α (HIF-1α) pathways, particularly leading to upregulation of VEGF expression in osteosarcoma microenvironment [31]. The gene discussed is HIF1A; the disease is osteosarcoma.