Consistent with the lack of a correlation between CHK1 transcript levels and LY2603618 IC50s in the primary patient samples, ectopic expression of CHK1 in THP-1 AML cell line had no impact on LY2603618 sensitivity, as assessed by MTT assay (Figure 1D, the western blot confirming overexpression was published previously [28]). The gene discussed is CHEK1; the disease is acute myeloid leukemia.