Since low levels of adiponectin is associated with the development of hypertension [44] and insulin resistance [45], it could be speculated that adiponectin is part of the link between UA and elevated blood pressure and insulin resistance, and explain why UA is associated with new onset elevated blood pressure and impaired fasting glucose in the overweight but not the normal-weight in our study. The gene discussed is ADIPOQ; the disease is hypertensive disorder.