AGT and hyperuricemia: Furthermore, a study found increased angiotensinogen levels in the hypertensive overweight (BMI ≥ 25 kg/m2), compared to the hypertensive normal-weight (BMI < 25 kg/m2), in the presence of hyperuricemia [46], and a rodent model demonstrated that UA-mediated upregulation of adipose RAAS caused insulin resistance [47].