ATXN3 and Cerebellar atrophy: Furthermore, in comparison with the AL-fed MJD mice, we observed that CR also decreases the neuropathology features of these mice, namely mediating an amelioration of cerebellar atrophy, molecular and granular layer thickness in the cerebellar cortex, while promoting a significant decrease in the aggregated and soluble forms of mutant ataxin-3 in Purkinje cells and in the cerebellar tissue.