ATXN3 and Spinocerebellar ataxia type 3: In this model of MJD, we stereotaxically inject lentiviral vectors encoding for a mutated form of ataxin-3 in the striatum of 5-week-old mice, inducing neuropathology from the second week on, including striatal mutant ataxin-3 inclusions, synaptic loss and astrogliosis3, 6, 7, 8, 9.