SIRT1 and Spinocerebellar ataxia type 3: In the present study we provide strong evidence demonstrating that CR robustly alleviates the neuropathology in two MJD mouse models (Tg and lentiviral MJD models) and rescues the motor impairments by a mechanism involving the upregulation of SIRT1, and consequent inhibition of neuroinflammation and activation of autophagy.