Taking this information into account, we evaluated neuroinflammatory markers in the affected brain region of MJD mouse models after CR regimen and we observed in the striatum of the lentiviral MJD mouse model a significant decrease of gliosis markers and mRNA levels of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), but no change on anti-inflammatory cytokine levels (IL-10). This evidence concerns the gene IL1B and Spinocerebellar ataxia type 3.