CXCL10 and diabetes mellitus: We could speculate that in some subjects, regardless DM or DM-induced cardiomyopathy, the higher CXCL10 level in blood likely derives from different cell and tissue types and could mirror a wider activation and amplification of the Th1-type response, during which sildenafil seems to be effective while it is neutral when CXCL10 is below the cut-off level, as from our ROC analysis data.