The mitotic inhibitor-sensitive cell lines also expressed low levels of NOTCH3, which has been linked to induction of apoptosis in HER2-negative breast cancer cell lines [29, 30]; of the small GTPase protein Rab25, which has been linked to aggressiveness of epithelial cancers [31]; of Bcl-2 and Stat3 high expression of which have been linked to the development of chemoresistance [32–34] and of the well-known driver of chemoresistance, HER2 [35, 36]. This evidence concerns the gene NOTCH3 and breast cancer.