In previous studies, MAPK signaling and KITLG, both of which participate in the circadian entrainment pathway, identified in association with the up‐regulated mRNAs, and the cytokine–cytokine receptor interactions, determined for down‐regulated mRNAs, were shown to be associated with the development of CRC cells 23, 24. The gene discussed is KITLG; the disease is colorectal carcinoma.