While the SEGRM CpdA did not reveal substantial protective capacities when tested in a model of noise-induced hearing loss in guinea pigs, analysis of more candidates of this class of drugs – potentially with a more stable molecular structure – is warranted to determine whether transactivation (possibly together with MR effects) is more important than transrepression in the function of glucocorticoids in the inner ear. This evidence concerns the gene NR3C2 and hearing loss disorder.