JAK2 and cancer: To explore whether miR-361-3p exerts its functions through the JAK2-SH2B1-Rac1 pathways that contribute to cancer proliferation, development and progression [20], we examined a number of the main SH2B1 signaling downstream target genes, including phosphorylation of Janus kinases 2(p-JAK2), phosphorylation of Rho GTPase Ras-related C3 botulinum toxin substrate 1(p-Rac1), cAMP-Protein Kinase Catalytic subunit (PKA), matrix metalloproteinase-2(MMP2), and MMP9.