Rac1 is a member of the Rho family of small GTPases and participates in numerous pathways inducing cytoskeleton reorganization, gene transcription, cell proliferation and survival [30, 31], especially in lung cancer modifies lung cancer migration, invasion and actin cytoskeleton rearrangements and enhances chemosensitivity to antitumor drugs [32, 33]. This evidence concerns the gene RHO and lung cancer.