Indeed, CAPRIN1, FMRP and HUD were detected in phospho-TDP-43 inclusions in spinal motor neurons in ALS patients (Fig. S5, S6; Supplementary Table S3) (80–100 % of pTDP-43 inclusions displayed immunolabeling for interactors). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.