We show that the interactors of multiple different ALS-associated proteins converge on a limited number of molecular complexes and related processes, namely RNA metabolism (ATXN2, FUS, hnRNPA1, hnRNPA2B1, MATR3 and TDP-43), autophagy and NF-κB signaling (OPTN, SQSTM1, TBK1, UBQLN2 and VCP) and mitochondrial functioning (C9orf72). Here, ATXN2 is linked to amyotrophic lateral sclerosis.