In conclusion, we report a novel dataset comprised interactomes of six ALS-associated proteins that will provide a framework for future studies into the pathogenic mechanisms underlying ALS or other diseases linked to the proteins studied here [e.g., frontotemporal dementia (FTD; C9orf72, FUS, TDP-43) or SCA2 (ATXN2)]). This evidence concerns the gene ATXN2 and amyotrophic lateral sclerosis.