To provide further insight into the pathogenic mechanisms underlying ALS and to determine the extent to which ALS-associated proteins share binding partners, we performed interactomics analyses for six ALS-associated proteins in neuronal cells: ATXN2, C9orf72, FUS, OPTN, TDP-43 and UBQLN2. Here, ATXN2 is linked to amyotrophic lateral sclerosis.