The interactors hnRNPA1, hnRNPA2B1, Matr3, FMRP and Prkra have previously been associated with neurodegenerative diseases (ALS, multisystem proteinopathy, fragile X-associated tremor/ataxia syndrome (FXTAS), fragile-X syndrome (FXS) and dystonia parkisonism). The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.