Our finding that FMRP rescues defects in neuromuscular junction (NMJ) morphology and aberrant motor behavior caused by mutant FUS in zebrafish together with recent work linking FMRP and TDP-43 [14] identifies FMRP as a shared component of the pathogenic mechanisms downstream of multiple ALS-associated proteins. The gene discussed is FMR1; the disease is amyotrophic lateral sclerosis.