A previous study revealed that fasting insulin level in WT + STZ mice is lower than 12-LOKO + STZ mice on Days 21 and 28 after STZ injection, and 12-LO elimination did not alter basal or glucose-stimulated islet insulin secretion in vitro [32]; suggesting that 12-LO inhibition is resistant to diabetes induction in different ways: 12-LO inhibition exerts a protective effect on pancreatic β-cell damage in type-1 diabetes and plays a pivotal role in the amelioration of IR in type-2 diabetes. This evidence concerns the gene INS and type 1 diabetes mellitus.