These results are consistent with a previous study, in which 12-LO specific inhibitor, N-benzyl-N-hydroxy-5-phenyl pentanamide (BHPP), could not inhibit albuminuria in STZ-induced type-1 diabetes mellitus [22], indicating that the inhibition of 12-LO exerts different effects on the progression of MAU in type-1 and type-2 diabetes. Here, ALOX12 is linked to type 1 diabetes mellitus.