After applying an integrated approach to accurately identify significantly mutated genes, Lawrence et al. have identified a short list of genes that have been previously reported to be associated with various types of cancers, such as TP53, CDKN2A, PIK3CA, PTEN, ERBB1, KEAP1, NFE2L2, NOTCH1 and FBXW7 [22]. The gene discussed is NOTCH1; the disease is cancer.