In one of the recent studies, Bruno et al. analyzed nine primary DLBCL CNS patients and identified recurrent somatic mutations in 37 genes involved in key biological processes, including transcription (ETV6, IRF2BP2, EBF1, IRF4, TBL1XR1), cell cycle (PIM1, BTG1), nucleosome assembly (HIST1H1D, HIST1H2AC) and cell adhesion (MUC16, ACTG1), as well as NF-κB, WNT and B-cell receptor signaling pathways [10]. This evidence concerns the gene TBL1XR1 and diffuse large B-cell lymphoma.