APOE and Stroke: Multiple susceptibility genes have been demonstrated to have a relationship with an enhanced risk of stroke or worse stroke prognosis, including F5, angiotensin-converting enzyme (ACE), methylenetetrahydrofolate reductase (MTHFR), serpin peptidase inhibitor 1 (SERPINE1), apolipoprotein E (APOE) [7], cytochrome P450 2C19 (CYP2C19) [8], and platelet-derived growth factor D (PDGF-D) [9], as well as chromosome 12p13 variants [10].