In conclusion, a study of interactive functioning of p75NTR and Trk receptors by using of immunological means may be a key approach for both the understanding of mechanisms of neuronal degeneration and the developing of effective new treatment applicable for AD [13], aging [39] and other neurodegenerative diseases associated with cholinergic system malfunctioning in the brain. This evidence concerns the gene NGFR and neurodegenerative disease.