Some studies showed that ADH1C*1 and ADH1B*2 are in linkage disequilibrium, suggesting that associations of ADH1C*1 with alcohol dependence may be attributed to correlation with ADH1B*2 (Borras et al. 2000; Chen et al. 1999a; Osier et al. 1999). This evidence concerns the gene ADH1C and alcohol dependence.