ADH1B and alcohol dependence: The ADH gene with the largest effect size with alcohol dependence is ADH1B. Significant associations have been found for the ADH1B*2 allele and alcohol dependence in Asian populations (Li et al. 2012a; Luczak et al. 2006a), as well as in European and African-American populations (Bierut et al. 2012; Whitfield 1997, 2002).