Similar to the results from meta- analyses showing that the ALDH2 and ADH1B genes may have an interactive effect on alcohol dependence (Luczak et al. 2006a), some self-report and alcohol-challenge data in Asians suggest that the effects of ADH1B*2 may be stronger in individuals with ALDH2*1/*2 genotype (e.g., Chen et al. 1999b; Cook et al. 2005; Luczak et al. 2006b; Takeshita et al. 1996, 2001). The gene discussed is ALDH2; the disease is alcohol dependence.