ALDH2 and alcohol dependence: In ALDH2*1/*1 individuals (i.e., ALDH2*1 homozygotes), one ADH1B*2 allele was associated with about one-fourth (OR = 0.26) and two ADH1B*2 alleles were associated with about one-fifth (OR = 0.20) the risk of alcohol dependence compared with individuals with no ADH1B*2 alleles.