A second ADH1B gene variant, the ADH1B*3 allele, has been related to lower rates of alcohol dependence in many but not all association studies (Edenberg 2007; Edenberg et al. 2006, 2010; Ehlers et al. 2001, 2007; Gizer et al. 2011; Luo et al. 2006; Wall et al. 1997a). The gene discussed is ADH1B; the disease is alcohol dependence.