GAD1 and psychiatric disorder: Reduction in GABA synthesis and its synaptic release machinery accompany loss of PV neurons in schizophrenia and other psychiatric disorders.4, 5, 6 Consistent with this, GAD67 mean fluorescence intensity in PV soma, the primary source of the enzyme pool, and in puncta across SP was significantly reduced in Fgf14−/− mice compared with littermate control (89.85%±3.08, 100%±3.96, P<0.05; and 91.86%±0.10, 100%±0.08, P<0.0001, respectively; Supplementary Figures 2A–D and Figures 2a–c).