Further, bioinformatics analysis of schizophrenia transcriptomics confirms FGF14 functional clustering with GABAergic synaptic signaling and identifies genetic covariance of FGF14, PVALB, GAD67 and VGAT in the disease, supporting Fgf14−/− mice as an attractive model to interrogate the biology of complex brain disorders associated with disrupted cognitive circuitry such as schizophrenia. This evidence concerns the gene GAD1 and schizophrenia.