In the first study, examining association of genes involved in circadian rhythms with BD, EGR3 was to sole gene that achieved a significance level of P<0.05.57 A second investigation, a family-based association study identified a nominal association of EGR3 with risk for child with BD I.56 These findings suggest that EGR3 may be a fruitful gene for future genetics studies to identify mechanisms by which environment and genetic predisposition interact to influence BD. This evidence concerns the gene EGR3 and Behcet disease.