For instance, amphetamine and cocaine increase EGR1 mRNA expression in the striatum,69 cocaine also induce EGR3 in the striatum25 and amphetamine or alcohol withdrawal induce EGR1 expression.70 Considering these observations, it seems unlikely that antipsychotic treatment, alcohol or other substances are responsible for our findings, as they induce EGR3 and other growth response genes, whereas our results pointed to the repression of the EGR3 regulon in BD signatures. Here, EGR3 is linked to Behcet disease.