As described previously15, we found both T1D and ND hiPSC to express pluripotent stem cell markers, differentiate to express markers of all three germ layers and, after undergoing planar differentiation to pancreatic progenitors, produce PDX1+/NKX6-1+ cells that can be transplanted into mice to spontaneously generate glucose-responsive cells in vivo (Supplementary Figs 1 and 2). The gene discussed is NKX6-1; the disease is type 1 diabetes mellitus.