Furthermore, immunohistochemical staining of continuous paraffin sections revealed the colocalization of the IL6, p-STAT3, HIF1A, and LC3B proteins in high-grade glioma tissues (Fig. S1), particularly in the hypoxic area around tumor vessels (Fig. 1B, the enlarged view of the lower right green box in Fig. S1). This evidence concerns the gene STAT3 and neoplasm.