Furthermore, immunohistochemical staining of continuous paraffin sections revealed the colocalization of the IL6, p-STAT3, HIF1A, and LC3B proteins in high-grade glioma tissues (Fig. S1), particularly in the hypoxic area around tumor vessels (Fig. 1B, the enlarged view of the lower right green box in Fig. S1). The gene discussed is IL6; the disease is central nervous system cancer.