Furthermore, immunohistochemical staining of continuous paraffin sections revealed the colocalization of the IL6, p-STAT3, HIF1A, and LC3B proteins in high-grade glioma tissues (Fig. S1), particularly in the hypoxic area around tumor vessels (Fig. 1B, the enlarged view of the lower right green box in Fig. S1). Here, MAP1LC3B is linked to central nervous system cancer.