It is well accepted that STAT3 serves as a downstream target of IL6, which induces STAT3 activation through tyrosine 705 phosphorylation and cytoplasmic-to-nuclear shuttling, recognition of STAT3-specific DNA motifs, and transcriptional activation of target genes that are implicated throughout tumor development and involved in proliferation, survival, invasion and angiogenesis.34,35. The gene discussed is IL6; the disease is neoplasm.