ESR1 and neoplasm: Reported studies have used various factors to predict LNM [7–11], such as magnetic resonance imaging (MRI) combined with cancer antigen 125 (CA125); tumor size with myometrial invasion and histological type and grade; and lymphovascular space involvement (LVSI) with immunostaining of estrogen receptor (ER) and progesterone receptor (PR) in endometrial lesion.