FN1 and Hepatic fibrosis: ITG αvβ3 interacts with several ECM proteins including vitronectin and fibronectin.29 ITG αvβ3 is expressed mainly on endothelial cells, and it plays an important role in endothelial cell migration.30 We investigated whether pharmacological inhibition of ITG αvβ3 and αvβ5 could block the engraftment of the expanded PB-CD34+ cells and worsen rat liver fibrosis.