Specifically, chronic Celecoxib treatment prevents the development of anhedonia after chronic unpredictable stress (Guo et al., 2009), and chronic COX-2 inhibition reduces immobilization stress-induced hypoactivity, memory deficits (Kumari et al., 2007), and anxiety-like behavior in the mirror chamber test (Dhir et al., 2006). The gene discussed is PTGS2; the disease is Anxiety.