NOS2 and Sepsis: In a model of sepsis, Bz used at a subcurative dose (25 mg/kg) showed immunomodulatory properties by inhibiting the expression of NF-κB and mitogen-activated protein kinase (MAPK) (p38 and extracellular signal-regulated kinase [ERK]), which are crucial for TNF and iNOS/NOS2 expression and NO production (27).