Of the 40 genes, 8 were independently identified as Mut-driver tumour suppressor genes using the ratiometric method described above: FOXO3, CTNNA1, FOXP1, MEN1, CHEK2 in ER+ tumours; CDKN2A, KDM6A and MLLT4 in both ER+ and ER− tumours. This evidence concerns the gene CHEK2 and neoplasm.