Mutual exclusivity between mutations in TP53 and each of CDH1 (OR=0.23, CI=0.14–0.36), GATA3 (OR=0.13, CI=0.069–0.23) and SF3B1 (OR=0.049, CI=0.0012–0.29) reflect opposite associations with tumour grade and histological type (Fig. 2). This evidence concerns the gene CDH1 and neoplasm.