The high rates of hypoglycaemia in patients with T1D in Northern Europe/Canada may partly be related to the duration of diabetes and duration of insulin use in this population, which, possibly as a result of better prognosis, were considerably higher than those for other regions (Table S2, Supporting Information), but the high rate of hypoglycaemia in T1D seen in Latin America compared with a region such as Eastern Europe, which has similar baseline population characteristics, may reflect regional differences in diabetes management. The gene discussed is INS; the disease is type 1 diabetes mellitus.