When examining how regional differences in hypoglycaemia in patients with T2D may relate to patient characteristics, it appears that patients in Russia and Eastern Europe were older, and had been receiving insulin therapy for longer than patients in the SE Asia and Middle East cohorts (longer disease duration and longer duration of insulin therapy were associated with increased rates of hypoglycaemia in the HAT study). The gene discussed is INS; the disease is type 2 diabetes mellitus.