ITGAM and acute lung injury: Thus, antitrombin III has been shown to inhibit cytokine and tissue factor production in endothelial cells [23], attenuate CD11b/CD18 expression in activated neutrophils and monocytes [24], suppress granule secretion in activated platelets [25], prevent apoptosis of hepatocytes [26, 27], and improve endotoxin-induced acute lung injury in rats [28].