Interestingly, subsequent association analysis of somatic mutations and gene expression changes in GBM identified SYNE1 as a major node; SYNE1 mutations have drastic effects on the expression of 543 genes, including mismatch repair genes MutS homolog 6 (MSH6) and MutL homolog 1 (MLH1). The gene discussed is SYNE1; the disease is glioblastoma.