We therefore conducted a case–control study to determine the influence of vitamin D status and single nucleotide polymorphisms (SNPs) in VDR, DBP and CYP2R1 on susceptibility to active TB in Pakistan, a high-burden setting where TB incidence in 2014 was estimated at 270 cases per 100,000 population per year [1]. Here, CYP2R1 is linked to tuberculosis.