In the first group object of this study, the MEK5 was overexpressed in 38.1 % of CRC tissues (32 out of 84); compared with 20.8 % of colorectal adenoma (5 out of 24) and 8.3 % of normal tissues (2 out of 24) (Fig. 1). This evidence concerns the gene MAP2K5 and colorectal adenoma.