TNF and Hepatitis: ConA–induced hepatitis involves cooperative activation of natural killer T (NKT) with conventional T cells and Kupffer cells and IL-4-, TNF-α- and IFN-γ-mediated liver inflammation in mice with subsequent development of hepatocellular apoptosis and necrosis [10–12] that eventually results in endothelium disintegration and necrosis of hepatocytes [10].