The high level of TGFβ in all tissues examined is the expected result for the uninflamed tissues (spleen and skin) in which TGFβ provides a tolerance threshold to maintain immune homeostasis and prevent autoimmunity [50] but is somewhat surprising for sarcoids, in which a large number of T-cells with blast morphology are present and would support the conclusion that the T-cells have a regulatory phenotype contributing to the high TGFβ. Here, TGFB1 is linked to Autoimmunity.