It plays a critical role in response to genotoxic stress and tries to maintain genomic stability and control proper execution of the cell cycle and apoptotic pathways.10, 11, 12 Deregulated function of p53 may result in loss of this regulation, resulting in uncontrolled cell proliferation and cancer development.13, 14, 15 Polymorphisms in p53 or target genes impair the function of the p53 signaling pathway.16 The most studied polymorphism in p53 is located in exon 4 at codon72. Here, TP53 is linked to cancer.