Downregulated PD-L1 resulted in enhanced apoptosis and weakened survival of tumor cells.40 Attenuated glycolysis by HK2 and PFKP ablation may sensitize MNK45 and SGC7901 cells to apoptosis induced by PD-L1 blocking.41, 42 All these effects can be achieved through HIF-1α inhibition caused by miR-186 overexpression. This evidence concerns the gene CD274 and neoplasm.