High p53 expression is known to correlate with increasing histological grade in chondrosarcoma27 and is suggestive for mutated TP53. 28 Wild-type p53 was shown to be able to repress survivin expression,17 which may explain the higher survivin expression in chondrosarcomas with high, probably mutated, p53 expression. The gene discussed is TP53; the disease is chondrosarcoma.