BIRC5 and soft tissue sarcoma: SurvivinΔEx3 has been most extensively studied and has been associated with a worse prognosis in breast, colon and cervical cancer.29 In soft tissue sarcomas, all survivin transcripts were strongly overexpressed compared with non-malignant control tissue and elevated expression of survivinΔEx3 was correlated with a worse survival.30 Survivin was expressed in normal growth plate tissue, suggesting a role for survivin in endochondral ossification.