BIRC5 and chondrosarcoma: On the other hand, cytoplasmic survivin is predominantly involved in preventing apoptosis.16 Overexpression is found in many tumor types including osteosarcomas22 and soft tissue sarcomas.23 Moreover, survivin upregulation was previously shown in small series of conventional chondrosarcomas.24, 25, 26 We here demonstrate high survivin expression in conventional as well as rare chondrosarcoma subtypes in a large panel of >200 chondrosarcomas.