Beside age, white blood cell count (WBC), somatically acquired mutations in the nucleophosmin 1 (NPM1) and fms-related tyrosine kinase 3 (FLT3-ITD) genes as well as a cytogenetic risk group factor are known to be important predictors in AML cases that need to be taken into account as mandatory covariates for adjustment. The gene discussed is FLT3; the disease is acute myeloid leukemia.