Beside age, white blood cell count (WBC), somatically acquired mutations in the nucleophosmin 1 (NPM1) and fms-related tyrosine kinase 3 (FLT3-ITD) genes as well as a cytogenetic risk group factor are known to be important predictors in AML cases that need to be taken into account as mandatory covariates for adjustment. Here, NPM1 is linked to acute myeloid leukemia.