Our results with combinatorial resveratrol and pterostilbene at a dose which is close to physiological-relevant concentrations not only significantly reactivates the ERα status via its effects on DNA methylation and histone acetylation in these ERα-negative breast cancer cells, but can also synergistically inhibit the viability of TNBC cells and decrease the expression of hTERT and SIRT1 (HDAC III), as published in our previous findings. This evidence concerns the gene ESR1 and breast cancer.