Another approach usesLactococcus lactis engineered to secrete PI and IL-10; in combination with low-dose parenteral anti-CD3, oral administration of these bacteria to freshly diabetic mice can induce lasting remission of T1D, possibly due to the induction of PI-specific regulatory T cells found in the intestinal mucosa and in islets56. The gene discussed is IL10; the disease is type 1 diabetes mellitus.