CD4 and type 1 diabetes mellitus: Applying this approach to stimulating CD4+ T cells by nanoparticles coated with MHC class II/peptide complexes, the group could now show that the novel strategy can not only prevent and revert T1D in the NOD model but also attenuate autoimmune inflammation in rodent models of collagen-induced autoimmune arthritis and in experimental autoimmune encephalomyelitis.