Injection of 10-week-old mice with a lentivirus, driving exclusive expression of B9–23 in hepatocytes due to a microRNA sequence, induces peptide-specific CD8+ T cells and regulatory T cells and halts the progression of T1D; combining the virus with low-dose anti-CD3 may induce remission of T1D57. Here, CD8A is linked to type 1 diabetes mellitus.