Similarly, Ferrara et al. demonstrated that a specific lectin secreted by Paneth cells, namely regenerating islet-derived 3-alpha (REG3alpha), has diagnostic value in acute GI GVHD permitting to differentiate between GVHD-related diarrhea and other causes of diarrhea.72 The authors also demonstrated a prognostic value of REG3alpha in GVHD, in particular, a positive correlation between plasma levels and NRM was found. The gene discussed is REG3A; the disease is graft versus host disease.