Methylation of DAPK1 and RASSF1 genes is known to strongly contribute to carcinogenesis, metastasis and treatment failure in various types of cancer (Wong, Chang, Tang, Wei, & Kwong, 2002; Supic, Kozomara, Brankovic-Magic, Jovic, & Magic, 2009). The gene discussed is RASSF1; the disease is cancer.