A study analyzing the genetic basis for Rotor syndrome [157], an autosomal recessive disorder, uncovered patients homozygous for a near full-length LINE-1 insertion (lacking 24 nt from the 5′-end relative to LINE-1.3) in intron 5 of solute carrier organic anion transporter family member 1B3 (SLCO1B3). This evidence concerns the gene SLCO1B3 and Rotor syndrome.