Our research found that treatment with H-SN1 exhibited a marked therapeutic effect on the clinical symptoms and histological damage of the inflamed colonic mucosa in DSS-induced murine colitis, and also affects the production of inflammatory mediators (i.e., TNF-α, IL-1β, IL-6, IFN-γ, and IL-10) and suppresses inflammatory cell infiltration. This evidence concerns the gene IL6 and colitis.