SMO and chronic myelogenous leukemia, BCR-ABL1 positive: Dierks et al. demonstrated that Hh signaling is upregulated in a pMSCV/Bcr-Abl/IRES-GFP retroviral vector murine model of CML and in their patient cohort, which was predominantly comprised of BC-CML, through upregulation of Smoothened (SMO)27.