LGALS3 and rheumatoid arthritis: Galectin-3 expression is increased in OA chondrocytes51, and increased galectin-3 immunohistochemical staining has been demonstrated at sites of synovial and cartilage invasion by immune cells in RA and during inflammatory phases of OA27, leading authors to hypothesize that galectin-3 is both involved in inflammation and a novel marker of disease activity in RA.