In the present study, we also demonstrated that 14-3-3ơ could interact with AKT and counteract LASP1-dependent activation of AKT kinase in CRC aggressiveness, suggesting 14-3-3ơ as a molecular regulator of AKT and as a potential anticancer agent for AKT-activated cancers. Here, AKT1 is linked to colorectal carcinoma.