Intriguingly, patients with high LASP1 and low 14-3-3σ had significantly worse outcome, and patients with low LASP1 and high 14-3-3σ had better outcome, indicating the opposing effects of LASP1 and 14-3-3σ on CRC patient survival (Fig. 6B). The gene discussed is LASP1; the disease is colorectal carcinoma.