MDM2 and cancer: Table 1 shows 25 statistically significant clusters (a significant level of 0.1 in FDC1) with the parameters of J = 25, M = 10, C = 2.0, d = 0.3 MB and r = 0.3 MB ordered by the cluster scores. Out of 18 silver standard genes, 10 genes, including EGFR, CDKN2A/B, CDK4, MDM4, PDGFRA, MDM2, PTEN, PARK2, and QKI, were identified. These genes were located in highly ranked clusters, showing that clusters with high scores might contain cancer driver genes. All genes included in the clusters are shown in Supplementary Table 5.