CTNNB1 and cancer: Figure 9 shows two samples with amplifications in CDK8, and these samples have the highest expression level in CDK8 (Supplementary Table 6). Previous studies showed that in colorectal cancers, the region around CDK8 is known to be recurrently altered, and the gene is reported to be a oncogene because it modulates beta-catenin activity28. In addition, we observed two amplifications around ZNF521. ZNF521 is listed in the COSMIC Cancer Gene Census (CGC) database29, and it was reported that overexpression of ZNF521 is closely related to the growth and proliferation of medulloblastoma cells30.