Our understanding of lung ILC2s has largely come from investigations into their role in patients with allergic asthma, where they have been characterized as important mediators of airway responsiveness, eosinophilia, and mucus production.12, 14, 18, 19, 20 Several studies have also shown that ILC2s can play a role in pathologic changes during influenza and rhinovirus infections through either IL-33 or IL-25, although the effect of TSLP on virus-induced ILC2 activation in the lungs remains unknown.15, 16, 17, 21, 26. This evidence concerns the gene TSLP and allergic asthma.